基于金属纳米簇的电化学发光分析应用研究进展

近年来,基于金属纳米簇结构的电化学发光(Electrochemiluminescence,ECL)特性发展新型分析检测方法已成为分析化学领域的研究热点.金属纳米簇作为一类介于分子和常规纳米颗粒之间的材料,其发光特性备受关注.本文对近年来基于金属纳米簇ECL分析的研究进展进行了评述,按配体分类简要介绍了与ECL相关的纳米簇的制备方法,以及纳米簇ECL研究的机制与应用,针对提高纳米簇ECL性能问题,重点讨论ECL增强和生物信号放大方法这两个主要的策略.此外,本文还对纳米簇在ECL体系中作为能量转移受体的应用进行了评述.

Progress of Metal Nanoclusters-based Electrochemiluminescent Analysis

In the past ten years, the development of electrochemiluminescent ( ECL ) analytical methods based on various types of nanostructures has become a research hotspot. Nanocluster, an intermediate between molecules and conventional nanoparticles, is renowned for its luminescent feature. The first report on ECL for nanoclusters can be traced back to 2009 . Here we summarized the main research progresses since 2011 . Firstly, the preparation of ECL-related nanoclusters was briefly introduced. Then, the mechanisms and applications of ECL by nanoclusters were described. To improve ECL performances, two main strategies, i. e. , nanostructure-based ECL enhancement and biological signal amplification were proposed. Besides, the nanoclusters as the energy transfer receptors in ECL systems were also discussed. In prospect part, the future development of ECL by nanoclusters was considered. We believed that the synthesis of high quality nanoclusters, the reveal of ECL structure-activity relationships, the rationale design and application of near-infrared ECL, and the role of ECL in the interdisciplinary research were the main problems we faced in the future.