One-step double reduction of aryl nitro and carbonyl groups using hydrazine |
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Authors: | Elena Diez-CeciliaBrendan Kelly Isabel Rozas |
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Institution: | School of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland |
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Abstract: | Single-step reduction of aryl nitro and carbonyl groups to the corresponding synthetically useful alkyl-anilines occurs with excellent yields by treatment with hydrazine and a base in a solvent-free reaction. The method has been applied to a broad range of compounds with different properties. Investigations into the mechanism of the reduction reveal that each group is reduced independently. A mechanism is proposed for this novel reduction of aromatic nitro groups. |
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Keywords: | Reduction Nitro Carbonyl Hydrazine |
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