Catalytic activities of modified hydrolytic enzymes in organic media : syntheses of optically active trifluoromethylated compounds

Modifications of hydrolytic enzymes by incorporation of fluorine-containing molecules have been found to improve the catalytic activity of the parent enzymes. Syntheses of optically active compounds possessing a trifluoromethyl group, via enzymatic chiral Michael addition reaction and synthesis of heterocycles, have been undertaken in organic solvents.