A convenient synthesis of ethyl 3,3,3,-trifluoropropanoate and its 2-bromo derivative |
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| Institution: | 1. Novel Drug Discovery & Development, Lupin Limited (Research Park), 46A/47A Village Nande, Taluka Mulshi, Pune 412 115, India;2. Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 567 104, India;1. Structural Materials Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan;2. Asahi Glass Co., ltd., 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, Japan;1. Department of Chemistry, Youngstown State University, Youngstown, OH 44555, United States;2. Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States;1. Department of Chemistry, ASET, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India;2. Department of Polymer Science, University College of Science, Mohanlal Sukhadia University, Udaipur, Rajasthan, India |
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| Abstract: | Ethyl 3,3,3-trifluoropropanoate and ethyl 2-bromo-3,3,3-trifluoropropanoate have been synthesized. A common intermediate ethyl 3-chloro (or 3-bromo)-3,3-difluoropropanoate is involved in the two syntheses. These esters are obtained by oxidation of the corresponding acetals resulting from the radical addition of CF2BrCl or CF2Br2 to ethyl vinyl ether. |
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