Synthesis of lupane triterpenoids with triphenylphosphonium substituents and studies of their antitumor activity |
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| Authors: | A. Yu. Spivak D. A. Nedopekina E. R. Shakurova R. R. Khalitova R. R. Gubaidullin V. N. Odinokov U. M. Dzhemilev Yu. P. Bel’skii N. V. Bel’skaya S. A. Stankevich E. V. Korotkaya V. A. Khazanov |
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| Affiliation: | 1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 prosp. Oktyabrya, 450075, Ufa, Russian Federation
2. Innovative Pharmacology Research (IPHAR), 8/8 prosp. Akademicheskii, 634055, Tomsk, Russian Federation
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| Abstract: | New derivatives of lupane triterpenoids, viz., 20,29-dihydrobetulinic and 3-epi-20,29-dihydrobetulinic acid derivatives containing triphenylphosphonium fragments as substituents were synthesized. These compound considerably exceed betulinic acid in antitumor activity. |
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