Synthesis, structures, and properties of 15-oxoisosteviol thiosemicarbazone and oxime |
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| Authors: | R. R. Sharipova O. A. Lodochnikova I. Yu. Strobykina R. Z. Musin V. M. Babaev V. I. Morozov S. N. Pod“yachev R. V. Chestnova V. E. Kataev |
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| Affiliation: | 1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation
2. Republic Clinical Antituberculosis Dispensary, Ministry of Health of Republic of Tatarstan, 27a ul. Sibirskii Trakt, 420088, Kazan, Russian Federation
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| Abstract: | New nitrogen-containing derivatives of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) containing oxo, hydroxyimine, and thiosemicarbazone groups were synthesized. Isosteviol 15-oxo-16-thiosemicarbazone forms a 1: 1 complex with CuII and inhibits the growth of Mycobacterium tuberculosis (H37RV, in vitro) at the minimum inhibitory concentration of 20 μg mL?1. |
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