Synthesis of enantiomerically pure macrolides with hydrazide fragments from tetrahydropyran and l-(+)-tartaric acid derivatives |
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| Authors: | G. Yu. Ishmuratov M. P. Yakovleva G. R. Mingaleeva M. A. Shutova R. R. Muslukhov E. M. Vyrypaev A. G. Tolstikov |
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| Affiliation: | 1. Institute of Organic Chemistry, Ufa Research Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation
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| Abstract: | A synthesis of two potentially useful bicyclic 26- and 33-membered macrolides containing 1,3-dioxolane and hydrazide fragments was developed starting from tetrahydropyran via a [1+1]-condensation of 7′-oxooctyl-7-oxooctanoate and bis(7-oxooctyl)hexanedioate with hydrazide of L-(+)-tartaric acid acetonide derivative. |
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