Cu(II)-nitroxyl radicals as catalytic galactose oxidase mimics |
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| Authors: | Dijksman Arné Arends Isabel W C E Sheldon Roger A |
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| Affiliation: | Laboratory for Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands. |
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| Abstract: | Results from Hammett correlation studies and primary kinetic isotope effects for the CuCl-TEMPO catalysed aerobic benzyl alcohol oxidations are inconsistent with an oxoammonium based mechanism. We postulate a copper-mediated dehydrogenation mechanism, in which TEMPO regenerates the active Cu(II)-species. This mechanism is analogous to that observed for Galactose Oxidase and mimics thereof. |
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