Room temperature palladium-catalyzed intramolecular hydroamination of unactivated alkenes |
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Authors: | Michael Forrest E Cochran Brian M |
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Affiliation: | University of Washington, Seattle, 98195-1700, USA. fmichael@chem.washington.edu |
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Abstract: | A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes is described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. The formation of hydroamination products rather than oxidative amination products is due to the use of a tridentate ligand on Pd which effectively inhibits beta-hydride elimination. |
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