Abstract: | It is proposed to use the chromogenic 2-[4-phenylazo)benzylsulfonyl]ethyl group, which can be eliminated by organic bases in aprotic solvents, for the protection of a C-terminal carboxy group in the synthesis of peptides. The synthesis of a number of 10–16-membered peptides corresponding to C-terminal fragments of the heavy chain of the hemagglutination of influenza virus of subtypes H1 and H3 has been performed with the use of this group.All-Union Scientific-Research Institute of Molecular Biology, Kol'tsovo, Novosibirsk Oblast. Vektor Scientific-Industrial Association, Ministry of the Medical and Biological Industry of the USSR, Novosibirsk. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 732–738, September–October, 1988. |