A practical synthesis of L-ribose |
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| Authors: | Akagi Masao Omae Daichi Tamura Yoshinori Ueda Tetsujiro Kumashiro Tetsuya Urata Hidehito |
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| Affiliation: | Osaka University of Pharmaceutical Sciences, Takatsuki, Japan. akagi@gly.oups.ac.jp |
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| Abstract: | L-Ribose was synthesized by a simple four-step method with overall yield of 76.3% from a protected L-arabinose derivative, which is a compatible intermediate for the synthesis of L-deoxyribose. The key step of this strategy is the Swern oxidation and subsequent stereoselective reduction accompanied by inversion of the 2-hydroxy group of protected L-arabinose. |
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