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| 中国南海红树内生真菌Microsphaeropsis sp.二氢异香豆素类化合物研究 | |
| 引用本文： | 魏美燕,胡谷平,郑彩娟,邵长伦,王长云,周世宁,佘志刚,林永成.中国南海红树内生真菌Microsphaeropsis sp.二氢异香豆素类化合物研究[J].中山大学学报(自然科学版),2010,49(2). |
| 作者姓名： | 魏美燕 胡谷平 郑彩娟 邵长伦 王长云 周世宁 佘志刚 林永成 |
| 作者单位： | 1. 广东医学院药学院,广东,东莞,523808 2. 中山大学化学与化学工程学院,广东,广州,510275 3. 中国海洋大学医药学院,山东,青岛,266003 |
| 基金项目： | 国家自然科学基金资助项目，广东医学院青年基金资助项目，中国海洋大学海洋药物教育部重点实验室开放基金(KLMD |
| 摘 要： | 首次研究了一株南海红树内生真菌Microsphaeropsis sp.的次级代谢产物。从该菌的培养液的乙酸乙酯相中分离获得8个二氢异香豆素单体化合物,运用现代波谱技术鉴定其结构分别为4-hydroxy-8-O-methylmellein(1),mellein(2),4-hydroxymellein(3),5-hydroxymellein(4),4-hydroxy-3,5-dimethylmellein(5),5-methylmellein(6),7-hydroxymellein(7),5-carboxymellein(8)。其中,化合物1为从自然界发现的新天然产物,化合物4,5,6,7,8为首次从海洋真菌Microsphaeropsissp.中分离得到的化合物。 |
| 关 键 词： | 红树林内生真菌 次级代谢产物 二氢异香豆素 |
Dihydroisocoumarin Derivatives of Mangrove Endophytic Fungus Microsphaeropsis sp. Isolated from the South China Sea |
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| WEI Meiyan,HU Guping,ZHENG Caijuan,SHAO Changlun,WANG Changyun,ZHOU Shining,SHE Zhigang,LIN Yongcheng.Dihydroisocoumarin Derivatives of Mangrove Endophytic Fungus Microsphaeropsis sp. Isolated from the South China Sea[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2010,49(2). | |
| Authors: | WEI Meiyan HU Guping ZHENG Caijuan SHAO Changlun WANG Changyun ZHOU Shining SHE Zhigang LIN Yongcheng |
| Institution: | WEI Meiyan1,HU Guping2,ZHENG Caijuan3,SHAO Changlun3,WANG Changyun3,ZHOU Shining2,SHE Zhigang2,LIN Yongcheng2(1.School of Pharmacy,Guangdong Medical College,Dongguan 523808,China,2.School of Chemistry , Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,3.School of Medicine , Pharmacy,Ocean University of China,Qingdao 266003,China) |
| Abstract: | The secondary metabolites of the mangrove endophytic fungus Microsphaeropsis sp.from the South China Sea were first studied.Eight dihydroisocoumarin derivatives were isolated from the ethyl acetate extract of the fermentation.Their structures were identified by comprehensive spectroscopic methods as 4-hydroxy-8-O-methylmellein(1),mellein(2),4-hydroxymellein(3),5-hydroxymellein(4),4-hydroxy-3,5-dimethylmellein(5),5-methylmellein(6),7-hydroxymellein(7) and 5-carboxymellein(8).Compound 1 was isolated as a natu... |
| Keywords: | mangrove endophytic fungus secondary metabolites dihydroisocoumarin |
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