| 人血清白蛋白与Cu(II)配合物的生物活性研究 |
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| 引用本文： | 盖爽爽,江名. 人血清白蛋白与Cu(II)配合物的生物活性研究[J]. 化学通报, 2018, 81(3): 253-257 |
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| 作者姓名： | 盖爽爽 江名 |
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| 作者单位： | 广西科技师范学院,教师教育学院,广西科技师范学院,教师教育学院 |
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| 摘 要： | Cu(II)配合物很有可能成为下一代的抗肿瘤药物。本文以2-氨基-5-氯苯酚和2-喹啉甲醛合成的席夫碱作为配体,与Cu(II)络合形成配合物1。分别对配合物1和其与人血清白蛋白(HSA)的复合物HSA-1进行体外抗肿瘤测试,发现HSA能提高配合物1的抗肿瘤活性,并降低了对正常细胞的毒性。通过线粒体膜电位等实验,可以推断出配合物1是通过线粒体通路诱导癌细胞凋亡。
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| 关 键 词： | Cu(II)金属配合物 细胞凋亡 线粒体膜电位 |
| 收稿时间： | 2017-11-18 |
| 修稿时间： | 2018-01-03 |
Biological properties of Cu(II) complex with human serum albumin |
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| Shuangshuang Gai and Ming Jiang. Biological properties of Cu(II) complex with human serum albumin[J]. Chemistry, 2018, 81(3): 253-257 |
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| Authors: | Shuangshuang Gai and Ming Jiang |
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| Affiliation: | Guangxi Science Technology Normal University,College of Teacher Education,Guangxi Science Technology Normal University,College of Teacher Education |
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| Abstract: | Copper (II) complexes are promising to be next generation anticancer drugs, so using 2-Amino-5-chlorophenol and 2-Quinolinecarbaldehyde as ligand synthesized copper(II) complex, namely complex 1. complex 1 and HSA-complex 1 have been tested against cancer cell lines in vitro respectively, these results indicted that HSA hence complex 1 induced apoptosis in cancer cells, whereas, recued cytotoxicity levels in normal cells. Mitochondrial membrane potential assays revealed copper(II) complex induced apoptosis might mediate via the mitochondrial pathway. |
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| Keywords: | Copper(II) complexes Cell apoptosis Mitochondrial membrane potential |
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