| 壳聚糖-聚丙烯酸复合水凝胶的药物控制释放行为 |
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| 引用本文： | 杨晓慈,任杰,姚萌奇,张晓燕,杨武.壳聚糖-聚丙烯酸复合水凝胶的药物控制释放行为[J].应用化学,2014,31(10):1143-1148. |
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| 作者姓名： | 杨晓慈 任杰 姚萌奇 张晓燕 杨武 |
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| 作者单位： | (西北师范大学化学化工学院 兰州 730070) |
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| 基金项目： | 甘肃省高校基本科研业务费基金资助项目(5001-109)Supported by the Basic Project of Science and Research of Colleges and Universities of Gansu Province |
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| 摘 要： | 以壳聚糖(Cs)和丙烯酸(AA)为原料，利用自由基聚合法制备了具有孔洞结构的复合水凝胶Cs-PAA，并研究了AA的量、交联剂的量、聚合温度和AA的中和度对水凝胶溶胀度的影响以及复合水凝胶对烟酸的控制释放。 结果表明，Cs-PAA复合水凝胶具有良好的pH值、离子强度敏感性，且溶胀度最高达1228 g/g，其在pH=686的缓冲溶液中的烟酸累积释放率明显大于其在pH=1.80的缓冲溶液，因此Cs-PAA水凝胶可作为肠口服药物的载体。
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| 关 键 词： | 复合水凝胶 溶胀度 药物释放 烟酸 |
| 收稿时间： | 2013-12-24 |
| 修稿时间： | 2014-02-06 |
Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels |
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| YANG Xiaoci,REN Jie,YAO Mengqi,ZHANG Xiaoyan,YANG Wu.Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels[J].Chinese Journal of Applied Chemistry,2014,31(10):1143-1148. |
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| Authors: | YANG Xiaoci REN Jie YAO Mengqi ZHANG Xiaoyan YANG Wu |
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| Institution: | (College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China) |
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| Abstract: | The chitosan(Cs) and acrylic acid(AA) were used to prepare the composite hydrogel(Cs-PAA) by radical polymerization method. The influences of reaction temperature, neutralization degree of acrylic acid, amounts of cross-linking agent and acrylic acid on the swelling degree of the composite hydrogels were investigated. In addition, the controlled release behaviors of prepared hydrogels for niacin were evaluated. The swelling degree of prepared hydrogels is up to 1228 g/g. It exhibits excellent pH and ionic strength sensitivity. The cumulative release rate in a pH=6.86 buffer solution is significantly higher than that in a pH=1.8 buffer solution. Therefore, the hydrogels can be used as carriers of intestinal oral drugs. |
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| Keywords: | composite hydrogel swelling degree drug release niacin |
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