| Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules |
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| 引用本文： | Juan Fang WU Ling Xin CHEN Guo An LUO Yong Suo LIU Yi Ming WANG Zhi Hong JIANG. Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules[J]. 中国化学快报, 2006, 17(3): 383-386 |
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| 作者姓名： | Juan Fang WU Ling Xin CHEN Guo An LUO Yong Suo LIU Yi Ming WANG Zhi Hong JIANG |
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| 作者单位： | Juan Fang WU1，Ling Xin CHEN1，Guo An LUO1*，Yong Suo LIU1，Yi Ming WANG1，Zhi Hong JIANG2 1 Department of Chemistry，Tsinghua University，Beijing 100084 2 School of Chinese Medicine，Hong Kong Baptist University，Kowloon Tong，Hong Kong |
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| 基金项目： | 国家科技攻关项目;中国博士后科学基金 |
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| 摘 要： | The advantages of berberine such as the anticancer1, antiinflammatory2 and no side effects of camptothecin1, have promoted the research in the mechanism of berberine with macrobiomolecules. In general, three different points of view have been presented on…
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| 关 键 词： | 毛细管电泳 dsDNA 药物分子 交互作用 黄连素 Hoechst 33258 DNA |
| 收稿时间： | 2005-08-22 |
Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules |
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| Juan Fang WU,Ling Xin CHEN,Guo An LUO,Yong Suo LIU,Yi Ming WANG,Zhi Hong JIANG. Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules[J]. Chinese Chemical Letters, 2006, 17(3): 383-386 |
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| Authors: | Juan Fang WU Ling Xin CHEN Guo An LUO Yong Suo LIU Yi Ming WANG Zhi Hong JIANG |
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| Abstract: | Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis (CZE). Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine. |
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| Keywords: | Capillary zone electrophoresis interaction berberine Hoechst 33258 DNA. |
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