An epiisopicropodophyllin aza analogue via palladium-catalyzed pseudo-domino cyclization |
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| Authors: | Poli Giovanni Giambastiani Giuliano |
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| Institution: | UMR 7611 CNRS, Université Pierre et Marie Curie, 4 Place Jussieu, Tour 44-45, Bo?te 183, F-75252, Paris, Cedex 05, France. poli@ccr.jussieu.fr |
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| Abstract: | A new aza analogue of epiisopicropodophyllin (the C-3 epimer of podophyllotoxin) has been synthesized exploiting two original strategic steps. Rings A/B and E are entered at an early stage via a cationic benzhydrylation process. A palladium-catalyzed pseudo-domino (Pd-PDOM) intramolecular process generates rings C/D in a single synthetic operation. |
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