A one-step fusion of 1,3-thiazine and pyrimidine cycles |
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| Authors: | Ryabukhin Sergey V Plaskon Andrey S Ostapchuk Eugeniy N Volochnyuk Dmitriy M Shishkin Oleg V Shivanyuk Alexander N Tolmachev Andrey A |
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| Affiliation: | Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine. ryabukhin@mail.enamine.net |
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| Abstract: | The chlorotrimethylsilane-promoted Biginelli type reactions of aldehydes, thiourea, and cyanoketones led to a diverse set of tetrahydropyrimidine-2(1H)-thiones. Under similar conditions, thioureas, benzaldehyde, and cyanoacetamide reacted to give first representatives of hexahydro-5H-pyrimido[5,4-e][1,3]thiazin-5-ones in high preparative yield. |
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