Effect of organic co-solvents on the solvation enthalpies of amino acids and dipeptides in mixed aqueous solutions |
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Authors: | V G Badelin E Yu Tyunina |
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Institution: | 1.Institute of Chemistry of Solutions,Russian Academy of Sciences,Ivanovo,Russia |
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Abstract: | Transition enthalpies (Δtr
H
o) of substances from water to binary solutions were calculated at 298.15 K on the basis of standard dissolution enthalpies
(Δsol
H
o) for six amino acids and five dipeptides in the mixtures of water with organic solvents of various chemical natures. The
enthalpy pair coefficients of interaction h
xy
for biomolecules with organic component of mixture were estimated within the formalism of the McMillan-Mayer theory. The
change in the character of the interaction of the components of solution was demonstrated in dependence on the physicochemical
properties of the solvent and nature of the side radical of the dissolved bioorganic substance. Quantitative estimation of
the type of interaction of the substance with the solvent was performed on the basis of correlation ratios relating the enthalpy
characteristics of bioorganic substances to properties of organic cosolvents. It was shown that in the solutions under study,
the effects of both the specific (mainly electron donor) and non-specific solvation of amino acids and peptides are observed. |
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Keywords: | |
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