Potassium peroxydisulfate as an efficient oxidizing agent for conversion of ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates |
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Authors: | H R Memarian A Farhadi |
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Institution: | 1. Department of Chemistry, Faculty of Science, University of Isfahan, 81746-73441, Isfahan, Iran
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Abstract: | Various ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates were oxidized to their corresponding ethyl pyrimidin-2(1H)- one-5-carboxylates by potassium peroxydisulfate in refluxing aqueous acetonitrile. The products were obtained in good to excellent yields. The effect of the nature of 4-substituent and also the nature of solvent play an important role on the rate of oxidation. |
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