STUDY ON ASYMMETRIC SYNTHESIS OF 19-NORSTEROIDS SYNTHESIS OF A NEW OPTICALLY ACTIVE SYNTHON, (2R, 3S)-( )-2-ETHYL-2-(3'-OXO-4'-ENE)-AMYL-3-ACETOXY-CYCLOPENTANONE 期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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STUDY ON ASYMMETRIC SYNTHESIS OF 19-NORSTEROIDS SYNTHESIS OF A NEW OPTICALLY ACTIVE SYNTHON, (2R, 3S)-( )-2-ETHYL-2-(3'-OXO-4'-ENE)-AMYL-3-ACETOXY-CYCLOPENTANONE

作者姓名：	周维善庄治平王钟麒

作者单位：	Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica，Shanghai Institute of Organic Chemistry，Academia Sinica

摘要：	This paper reports the synthesis of a new optically active synthon 6 for the asymmetricsynthesis of 19-norsteroids. Symmetric trione 9 obtained by the reaction of γ-carbonyl sulfo-xide 12b with 2-cthyl-1, 3-cyclopetanedione 8, was reduced asymmetrically by Saccharomycescerevisiae to (2R,3S)-(-)-14 and subsequently transformed into (2R,3S)-( )-6 by a shortreaction sequence. The absolute configuration of the asymmetrical product, (2R, 3S)-(-)-14,was established by converting it into the known compound (2R, 3S)-( )-17.
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