Asymmetric cobalt-catalyzed Diels-Alder reactions of a boron-functionalized 1,3-diene with alkynes and allylboration with aldehydes |
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Authors: | Hilt Gerhard Hess Wilfried Harms Klaus |
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Institution: | Fachbereich Chemie, Philipps-Universit?t Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany. hilt@chemie.uni-marburg.de |
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Abstract: | Structure: see text] A cobalt(I)-catalyzed Diels-Alder reaction of a 1-boron-functionalized 1,3-diene is the key step in a one-pot reaction interconnecting three simple starting materials to obtain a multifunctionalized product. This product incorporates a stereogenic quaternary center next to a stereogenic secondary alcohol functionality generated with a very high degree of regio- and diastereoselectivity and good enantioselectivity in the presence of a chiral ligand such as (S,S)-Norphos. |
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