Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives |
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| Authors: | Dong Chen Xin Zhai Qiu Hui Yuan Jian Luo Si Chang Xie Ping Gong |
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| Institution: | Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100 μmol/L. Compounds 14c, 14d, and 14e showed significant inhibitory activity to the viral antigen HBeAg. |
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| Keywords: | 1H-Benzimidazol-5-ol Synthesis Anti-HBV activity |
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