Preparation and characterization of manganese ferrite-based magnetic liposomes for hyperthermia treatment of cancer |
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| Authors: | Pallab Pradhan Jyotsnendu Giri Rinti Banerjee Jayesh Bellare Dhirendra Bahadur |
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| Affiliation: | 1. School of Biosciences and Bioengineering, Mumbai, India;2. Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, Mumbai 400076, India |
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| Abstract: | Comparative evaluation of two different methods of magnetic liposomes preparation, namely thin film hydration (TFH) and double emulsion (DE) with different molar ratios of egg-phosphatidyl choline (egg-PC) and cholesterol using lauric acid coated manganese ferrite-based aqueous magnetic fluid, is reported. TFH was found to be a better method of encapsulation and TFH 2:1 (egg-PC: cholesterol) magnetic liposomes showed the highest encapsulation efficiency and comparable heating ability to that of magnetic fluids. Stealth TFH 2:1 magnetic liposomes containing DSPE-PEG2000 were three-fold more cytocompatible as compared to the magnetic fluid. Stealth TFH 2:1 manganese ferrite-based magnetic liposomes might be useful for hyperthermia treatment of cancer. |
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| Keywords: | Magnetic fluid Magnetic liposome Thin film hydration Heating ability Cytocompatibility |
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