New type of biosensor based on magnetic nanoparticle detection |
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Authors: | Petr I Nikitin Petr M Vetoshko Tatiana I Ksenevich |
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Institution: | 1. Natural Science Center of General Physics Institute, Russian Academy of Sciences, 38, Vavilov St, Moscow 119991, Russia;2. Institute of Radioengineering and Electronics, Russian Academy of Sciences, 11, Mokhovaya St., Moscow 103907, Russia |
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Abstract: | A new type of biosensor has been developed based on detection of nanosized superparamagnetic particles that serve as labels in bioreactions. The method is based on non-linear magnetic material detection by a magnetic field having components at two frequencies f1 and f2. The response is measured at the combinatorial frequencies fi=mf1+nf2, where m and n are integers, e.g., fi=f1±2f2. Several highly sensitive readers of superparamagnetic particles have been designed and used for development of various formats of immunoassays, including those compatible with immunoconcentration and magnetic enrichment of antigens. |
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Keywords: | Magnetic bead Non-linear magnetic material Detection at combinatorial frequency Immunoassay Antigen Antibody |
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