In vitro study of ferromagnetic stents for implant assisted-magnetic drug targeting |
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| Authors: | Misael O Avilés Haitao Chen Armin D Ebner Axel J Rosengart Michael D Kaminski James A Ritter |
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| Institution: | 1. Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA;2. Departments of Neurology and Surgery (Neurosurgery), The University of Chicago and Pritzker School of Medicine, Chicago, IL 60637, USA;3. Chemical Engineering Division, Argonne National Laboratory, Argonne, IL 60439, USA |
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| Abstract: | Implant-assisted-magnetic drug targeting (IA-MDT) was studied in vitro using a coiled ferromagnetic wire stent made from stainless steel 430 or 304, and magnetic drug carrier particle (MDCP) surrogates composed of poly(styrene/divinylbenzene) embedded with 20 wt% magnetite. The fluid velocity, particle concentration, magnetic field strength, and stent material all proved to be important for capturing the MDCP surrogates. Overall, this in vitro study further confirmed the important role of the ferromagnetic implant for attracting and retaining MDCPs at the target zone. |
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| Keywords: | Implant assisted-magnetic drug targeting Magnetic drug targeting Intravascular ferromagnetic stent Drug delivery Magnetic drug carrier particle In vitro |
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