Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy |
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Authors: | Rudolf Hergt Silvio Dutz |
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Affiliation: | Institute for Physical High Technology, Albert-Einstein-Strasse 9, D-07745 Jena, Germany |
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Abstract: | Loss processes being relevant for magnetic particle hyperthermia are analysed with respect to specific loss power under the condition of a limitation of the alternating magnetic field amplitude and frequency. Extrapolations to the maximum specific loss power of magnetic nanoparticles are discussed and conclusions are drawn with respect to the minimum particle concentration being necessary for hyperthermia or thermoablation under intra-tumoural or systemic particle supply. As a result, much efforts are necessary to render magnetic particle hyperthermia a valuable tumour therapy keeping at least part of the promises found in literature. |
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Keywords: | Hyperthermia Loss Magnetosome Magnetic nanoparticle Relaxation Targeting |
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