Quadrupole magnetic field-flow fractionation: A novel technique for the characterization of magnetic nanoparticles |
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Authors: | Francesca Carpino Maciej Zborowski P Stephen Williams |
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Institution: | 1. Department of Chemistry, Cleveland State University, 2351 Euclid Avenue, Cleveland, OH 44115, USA;2. Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA |
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Abstract: | Quadrupole magnetic field-flow fractionation (MgFFF) is an analytical separation and characterization technique for nano- and micro-sized magnetic particles. It fractionates particles according to their content of magnetite or other magnetic material. The potential and versatility of MgFFF for separation and characterization of magnetic nanoparticles, such as those used for immunospecific labeling of biological cells for magnetic separation, is demonstrated. A broadly polydisperse sample of dextran-coated magnetite nanoparticles was eluted under programmed field decay conditions, and quantitative data concerning the distribution of magnetite content were determined from the elution profile using a data reduction method. |
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Keywords: | Field-flow fractionation Magnetic field-flow fractionation (MgFFF) Magnetic nanoparticles Nanoparticle characterization Quadrupole magnetic field |
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