Magnetic nanoparticles for local drug delivery using magnetic implants |
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| Authors: | Rodrigo Fernández-Pacheco Clara Marquina J Gabriel Valdivia Martín Gutiérrez M Soledad Romero Rosa Cornudella Alicia Laborda Américo Viloria Teresa Higuera Alba García J Antonio García de Jalón M Ricardo Ibarra |
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| Institution: | 1. Instituto Universitario de Investigación en Nanociencia de Aragón (INA), Universidad de Zaragoza, Edif. Inter. II, 50009 Zaragoza, Spain;2. Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza, Facultad de Ciencias, 50009 Zaragoza, Spain;3. Hospital Clínico Universitario “Lozano Blesa”, Avda Gomez Laguna, 50009 Zaragoza, Spain;4. Dpto. de Patología Animal, Facultad Veterinaria, Universidad de Zaragoza, Miguel Servet,177, 50013 Zaragoza, Spain |
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| Abstract: | Magnetic nanoparticles are good candidates used for the targeted delivery of anti-tumor agents. They can be concentrated on a desired region, reducing collateral effects and improving the efficiency of the chemotherapy. We propose a method in which permanent magnets are implanted by laparoscopic technique directly in the affected organ. This method proposes the use of Fe@C nanoparticles, which are loaded with doxorubicin and injected intravenously. The particles, once attracted to the magnet, release the drug at the tumor region. This method seems to be more promising and effective than that based on the application of external magnetic fields. |
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| Keywords: | 87 83 +a 47 63 mh |
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