| 三唑硫酮氨席夫碱吗啡亚甲胺的超声辐射合成及其生物活性 |
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| 引用本文： | 郑玉国,薛伟,魏学. 三唑硫酮氨席夫碱吗啡亚甲胺的超声辐射合成及其生物活性[J]. 应用化学, 2010, 27(10): 1165-1171. DOI: 10.3724/SP.J.1095.2010.90820 |
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| 作者姓名： | 郑玉国 薛伟 魏学 |
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| 作者单位： | (贵州大学精细化工研究开发中心，教育部绿色农药和农业生物工程重点实验室 贵阳 550025) |
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| 基金项目： | 贵州省十一五农业攻关，贵州省自然科学基金 |
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| 摘 要： | 在超声辐射和常规加热条件下合成了11个未见报道的1-(吗啡啉亚甲基)-3-(3,4,5-三甲氧基苯基)-4-(取代次甲亚胺基)-1,2,4-三唑-5-硫酮. 其结构经1H NMR、13C NMR、IR以及元素分析确证。初步生物活性测试结果表明, 在500 mg/L浓度下化合物对黄瓜花叶病毒(CMV)有一定抑制活性。
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| 关 键 词： | 超声波辐射 三唑 亚胺 合成 |
| 收稿时间： | 2009-12-07 |
| 修稿时间： | 2010-02-20 |
Ultrasonic Radiative Synthesis and Biological Activities of Morpholinomethylamino Containing 1,2,4-Triazole-5-thiones |
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| ZHENG Yu-Guo,XUE Wei,WEI Xue. Ultrasonic Radiative Synthesis and Biological Activities of Morpholinomethylamino Containing 1,2,4-Triazole-5-thiones[J]. Chinese Journal of Applied Chemistry, 2010, 27(10): 1165-1171. DOI: 10.3724/SP.J.1095.2010.90820 |
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| Authors: | ZHENG Yu-Guo XUE Wei WEI Xue |
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| Affiliation: | (Key Laboratory of Green Pesticide and Bioengineering,Ministry of Education,Research and ;Development Center for Fine Chemicals,Guizhou University,Guiyang 550025) |
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| Abstract: | Eleven novel 1-(morpholinomethyl)-3-(3,4,5-trimethoxyphenyl)-4-substitute deneamino-1,2,4-triazole-5-thiones were designed and synthesized by mean of an ultrasonic radiation method and a ordinary heating process. Their structures were characterized by 1H NMR, 13C NMR, IR and elemental analyses. Preliminary bioassay showed that some of them exhibit certain inactivities to Cucumber mosaic virus(CMV). |
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| Keywords: | ultrasonic irradiation triazole Imines synthesis |
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