Replacement of plasma by high molecular weight substances

In the course of the development work, natural and synthetic polymers were examined to see whether they were suitable for use as plasma substitutes. The criteria of a plasma substitute are discussed in this connection. The most important of the base substances used at present (dextran, modified gelatin, polyvinylpyrrolidone, and hydroxyethyl starch) are described, and a typical example of proven therapeutic value is discussed for each type.