Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids. |
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| Authors: | K Shibata S Takegawa N Koizumi N Yamakoshi E Shimazawa |
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| Institution: | Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan. |
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| Abstract: | 2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene- 3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat. |
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