Microwave-mediated synthesis of a cyclic heptapeptoid through consecutive Ugi reactions |
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Authors: | Angélica de Fátima S Barreto Carlos Kleber Z Andrade |
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Institution: | Laboratório de Química Metodológica e Orgânica Sintética, Instituto de Química, Universidade de Brasília, 70910-970, Brasília, DF, Brazil |
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Abstract: | The combination of consecutive Isocyanide-based Multicomponent Reactions (IMCRs) allowed the synthesis of a cyclic heptapeptoid in a reduced number of steps. Herein, we describe this efficient approach using four consecutive Ugi reactions, being three Ugi four-center, four-component reactions, and one Ugi four-center, three-component reaction. Our strategy involved eight steps of which seven in a row were microwave-assisted with reaction times of 3–5?min and yields ranging from 88 to 98%. |
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Keywords: | Cyclic peptoids Consecutive Ugi reactions Isocyanide-based multicomponent reactions (IMCRs) Microwave-mediated reactions Macroheterocycles |
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