Development of a reductive Hosomi-Sakurai reaction |
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Authors: | Adriano Bauer Nuno Maulide |
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Institution: | Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria |
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Abstract: | Herein we present a full account on the reductive Hosomi-Sakurai reaction along with some insight into the reaction mechanism. Stereoselectivity appears to be highest when the crucial carbocation intermediate, derived by protonation of the homoallylic ether, is sufficiently stabilized to ensure that the hydride transfer becomes rate-determining. This hypothesis is supported by experiment and mechanistic analysis. |
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Keywords: | Hosomi-Sakurai Internal redox Metal free Hydride transfer acetal |
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