Fluorodaturatin und Homofluorodaturatin—zwei neue β-Carbolinderivate in Samen von

In the transverse section of the seeds ofDatura stramonium L. var.stramonium a conspicuous sea-green fluorescence under UV-light (365 nm) can be observed. Thinlayer chromatography of a methanolic extract shows many blue and sea-green fluorescing substances, the main component being a polar, sea-green fluorescing compound. This substance is characteristic for all of the four varieties ofDatura stramonium L., and therefore of taxonomic interest. Isolation was tried by means of different chromatographic techniques. Combination of column chromatography and preparative thinlayer chromatography allowed the isolation of the main product, which was shown to consist of two substances (GF andGFa). Application of chemical and spectroscopic methods established the structure ofGF, named Fluorodaturatin, as 2,3,5,6-Tetrahydro-9-hydroxy-1H-pyrido-1,2,3-l, m]--carboline-3-one. The second substanceGFa, called Homofluorodaturatin, was identified as analogue ofGF and the structure could be determined as 1,2,3,4,6,7-Hexahydro-10-hydroxyazepino-1,2,3-l, m]--carboline-4-one.

Teil der DissertationI. Maier, Universität Wien, 1981; Auszugsweise vorgetragen bei der 2. Wissenschaftlichen Tagung der Österreichischen Pharmazeutischen Gesellschaft, 17. bis 19. Mai 1981, Graz.