| 融合干扰素rPoIFN-α/β联合黄芪多糖抗病毒活性研究 |
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| 引用本文： | 郑鸣,王永芬,边传周,王老七.融合干扰素rPoIFN-α/β联合黄芪多糖抗病毒活性研究[J].河南师范大学学报(自然科学版),2014(6):119-123. |
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| 作者姓名： | 郑鸣 王永芬 边传周 王老七 |
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| 作者单位： | 河南牧业经济学院生物工程系 |
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| 基金项目： | 河南省高等学校青年骨干教师资助计划项目(2011GGJS-192) |
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| 摘 要： | 以融合干扰素rPoIFN-α/β和黄芪多糖(APS)作为抗病毒药物,采用MTT法与细胞病变(CPE)抑制试验评价了二者联用抗PRRSV,CSFV和PRV 3种猪源性病毒的效果.结果显示,融合干扰素rPoIFN-α/β和黄芪多糖(APS)联合使用对PRRSV,CSFV和PRV 3种猪源性病毒抑制作用远远高于单独使用,体现出显著的协同抗病毒效应,为融合干扰素与黄芪多糖的联合用药防控病毒性疾病提供了理论基础.
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| 关 键 词： | 融合干扰素 黄芪多糖 抗病毒活性 |
Antiviral Activity of Joint Application of Fusion Interferon rPoIFN-α/β and Astragalus Polysaccharin |
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| ZHENG Ming;WANG Yongfen;BIAN Chuanzhou;WANG Laoqi.Antiviral Activity of Joint Application of Fusion Interferon rPoIFN-α/β and Astragalus Polysaccharin[J].Journal of Henan Normal University(Natural Science),2014(6):119-123. |
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| Authors: | ZHENG Ming;WANG Yongfen;BIAN Chuanzhou;WANG Laoqi |
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| Institution: | ZHENG Ming;WANG Yongfen;BIAN Chuanzhou;WANG Laoqi;College of Bioenyinecring,Henan University of Animal Husbandry and Economy; |
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| Abstract: | In this study,we selected fusion interferon rPoIFN-α/βand Astragalus Polysaccharin(APS)as antiviral drugs,and evaluated the antiviral activities of joint application of rPoIFN-α/βand APS to PRRSV,CSFV and PRV by CPE and MTT methods.The results suggested the inhibitive effects of rPoIFN-α/βand APS on PRRSV,CSFV and PRV were more significant than those of rPoIFN-α/βor APS alone.There were obviously synergistic antiviral effects between rPoIFN-α/βand APS.The research could provide a theoretical foundation for jointly using rPoIFN-α/βand APS to control porcine viral diseases. |
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| Keywords: | fusion interferon Astragalus Polysaccharin antiviral activity |
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