Synthesis and Biological Activity of Four Adrenocorticotropin-(1-24)-tetracosapeptide Analogues with N-Terminal Deletions of Four to Seven Amino-Acid Residues

The syntheses of adrenocorticotropin-(5–24)-eicosapeptide, -(6–24)-nonadecapeptide, -(7–24)-octadecapeptide, and -(8–24)-heptadecapeptide are described. Their biological activities on isolated adrenal cortex cells and adipocytes, on superfused adrenal tissue, as well as on the adenylate cyclase system of isolated cell membranes are summarized.