Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition |
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| Authors: | Tingting Zou Yuka Sato Shuma Kaneyoshi Kota Mano Rui Yasukawa Yoshifumi Nakano Satoshi Fujii Shinobu Sato Shigeori Takenaka |
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| Affiliation: | 1.Department of Applied Chemistry, Kyushu Institute of Technology, Fukuoka 804-8550, Japan; (T.Z.); (Y.S.); (S.K.); (K.M.); (R.Y.); (Y.N.);2.Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka 820-8502, Japan; |
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| Abstract: | Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex. |
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| Keywords: | naphthalene diimide, β -cyclodextrins (β -CyDs), parallel G-quadruplex, DNA, RNA, nucleobase inclusion, apyromidinic sites, c-myc, c-kit, telomere RNA |
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