Milk and serum standard reference materials for monitoring organic contaminants in human samples |
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Authors: | Michele M. Schantz Gauthier Eppe Jean-François Focant Coreen Hamilton N. Alan Heckert Rebecca M. Heltsley Dale Hoover Jennifer M. Keller Stefan D. Leigh Donald G. Patterson Jr Adam L. Pintar Katherine E. Sharpless Andreas Sjödin Wayman E. Turner Stacy S. Vander Pol Stephen A. Wise |
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Affiliation: | 1. Analytical Chemistry Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, MD, 20899, USA 2. Mass Spectrometry Laboratory, University of Liège, Allée de la Chimie, 4000, Liège, Belgium 3. AXYS Analytical Services Ltd, 2045 Mills Road West, Sidney, BC, V8L 5X2, Canada 4. Statistical Engineering Division, NIST, 100 Bureau Drive, Gaithersburg, MD, 20899, USA 5. Analytical Chemistry Division, NIST, 331 Fort Johnson Road, Charleston, SC, 29412, USA 7. Aegis Sciences Corporation, 345 Hill Avenue, Nashville, TN, 37210, USA 6. Organic Analytical Toxicology, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA 8. EnviroSolutions Consulting, Inc., 4921 Bull Creek Road, Auburn, GA, 30011, USA
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Abstract: | Four new Standard Reference Materials (SRMs) have been developed to assist in the quality assurance of chemical contaminant measurements required for human biomonitoring studies, SRM 1953 Organic Contaminants in Non-Fortified Human Milk, SRM 1954 Organic Contaminants in Fortified Human Milk, SRM 1957 Organic Contaminants in Non-Fortified Human Serum, and SRM 1958 Organic Contaminants in Fortified Human Serum. These materials were developed as part of a collaboration between the National Institute of Standards and Technology (NIST) and the Centers for Disease Control and Prevention (CDC) with both agencies contributing data used in the certification of mass fraction values for a wide range of organic contaminants including polychlorinated biphenyl (PCB) congeners, chlorinated pesticides, polybrominated diphenyl ether (PBDE) congeners, and polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) congeners. The certified mass fractions of the organic contaminants in unfortified samples, SRM 1953 and SRM 1957, ranged from 12 ng/kg to 2200 ng/kg with the exception of 4,4′-DDE in SRM 1953 at 7400 ng/kg with expanded uncertainties generally <14 %. This agreement suggests that there were no significant biases existing among the multiple methods used for analysis. Figure Comparison of Concentrations of Selected Compounds in Human Serum and Human Milk Standard Reference Materials (SRMs) |
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