Detection and distinguishability of leukemia cancer cells based on Au nanoparticles modified electrodes |
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Authors: | Hong-Li Hu Hui Jiang Xue-Mei Wang Bao-An Chen |
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Institution: | aState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096, PR China;bZhongda Hospital, School of Clinic Medical, Southeast University, Nanjing 210096, PR China |
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Abstract: | The Au nanoparticles (Au NPs) modified interface has been fabricated by multi-potential step electrodeposition in this study. Based on the nano-Au interface, we have proposed an electrochemical approach to detect the cancer cell numbers sensitively with a detection limit of about 500 cells. More interestingly, the drug sensitive leukemia K562 cells and drug resistant leukemia K562/adriamycin could be electrochemically distinguished on the interface by the oxidation potential, which did not show any evident differences on the bare electrode. These results indicate the promising application of this nano-interface for constructing the unlabeled potential-discriminative cell biosensors. |
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Keywords: | Au nanoparticles Leukemia cancer cells Electrodeposition Electrochemical biosensors |
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