Study of dosimetric properties of acetylsalicylic acid in pharmaceutical preparations by EPR spectroscopy |
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| Authors: | J M Juárez-Calderón A Negrón-Mendoza V Gómez-Vidales S Ramos-Bernal |
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| Institution: | (1) Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, UNAM, A.P. 70-543, Ciudad Universitaria, Del. Coyoacán, 04510 México D.F, Mexico;(2) Instituto de Química, Universidad Nacional Autónoma de México, UNAM, Mexico, Mexico |
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| Abstract: | Electron paramagnetic resonance (EPR) was used to investigate the dosimetric properties of two pharmaceutical preparations containing acetylsalicylic acid, Aspirin® and Cafiaspirin®. The EPR spectra of the irradiated samples were found to have an asymmetric absorption characterized by a major resonance at g = 2.0033. Dose response was investigated between dose ranges of 2 to 95 kGy for 60Co-gamma rays. Fading characteristics and dependence on temperature irradiation were also studied. We suggest that commercial Aspirin® and Cafiaspirin® tablets can be used as dosimeters in the case of a short accident. |
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