| 2,5-取代-1,3,4-噁二唑化合物库的固相合成 |
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| 引用本文： | 黄文强,侯信,李晨曦,何炳林.2,5-取代-1,3,4-噁二唑化合物库的固相合成[J].离子交换与吸附,1998(2). |
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| 作者姓名： | 黄文强 侯信 李晨曦 何炳林 |
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| 作者单位： | 南开大学吸附分离功能高分子材料国家重点实验室!高分子化学研究所，元素有机化学国家重点实验室，天津，300071，南开大学吸附分离功能高分子材料国家重点实验室!高分子化学研究所，元素有机化学国家重点实验室，天津，300071，南开大学吸附分离功能高分子材料国家重点实验室!高分子 |
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| 摘 要： | 本文使用组合化学方法以聚苯乙烯亚磺酸钠树脂（1）为载体合成了2，5-取代-1，3，4-二唑化合物库。树脂1首先与溴代乙酸乙酯反应生成聚合物支载的乙酸酯（2）。肼解后所得的肼树脂进一步与取代的苄氯反应得双欧讲树脂（4）。树脂4与三氯氧磷回流得聚合物支载的2，5-取代-1，3，4-二唑（5）。用W-溴代乙酰苯酮烷基化后聚合物支载的产物用三乙胺解脱得2-芳基-5-芳甲酰亚乙烯基-1，3，4-二唑化合物库，产率15％-36％。
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| 关 键 词： | 2-芳基-5-芳甲酰亚乙烯基-1，3，4-噁二唑 固相合成 组合化学 |
SOLID-PHASE SYNTHESIS OF 2, 5-SUBSTITUTED-1, 3, 4-OXADIAZOLE COMPOUND LIBRARY |
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| Huang Wenqiang, Hou Xin ,Li Chenxi ,He Binglin.SOLID-PHASE SYNTHESIS OF 2, 5-SUBSTITUTED-1, 3, 4-OXADIAZOLE COMPOUND LIBRARY[J].Ion Exchange and Adsorption,1998(2). |
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| Authors: | Huang Wenqiang Hou Xin Li Chenxi He Binglin |
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| Abstract: | A 2, 5-substituted-1, 3, 4-oxadiazole library was synthesized by means of coinbinatorial chemistry technique on polystyrene sodium sulfinate (1 ) as a support.Resin 1 reacted firstly with ethyl bromoacetate to yield polymer-supported acetate (2). After hydrazinolysis, hydrazide resin (3 ) reacted further with substituted benzoyl chloride obtaining hydrazide resin (4). Resin (4 ) refluxed with phosphorus oxychloride to produce polymer-supported 2, 5-substituted--1, 3, 4-oxadiazole (5 ).After alkylated with w-bromoac e top henones, polymer- supperted products were cleaved using triethylamine obtaining 2-aryl-5-arylformylvinylene-1, 3, 4-oxadiazoles with yields of 15%-36%. |
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| Keywords: | 2-aryl-5-arylformylvinylene-1 1 3 4 - ox adiazole solid phase synthesis Combinatorial chemistry |
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