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Synchronous ultrasonic Doppler imaging of magnetic microparticles in biological tissues |
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| Authors: | Michael Ph Pyshnyi Svetlana V Pyshnaya Galina S Nechitailo Anatoly A Kuznetsov |
| Institution: | Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, Russia |
| Abstract: | We considered applicability of acoustic imaging technology for the detection of magnetic microparticles and nanoparticles inside soft biological tissues. Such particles are widely used for magnetically targeted drug delivery and magnetic hyperthermia. We developed a new method of ultrasonic synchronous tissue Doppler imaging with magnetic modulation for in vitro and in vivo detection and visualization of magnetic ultradisperse objects in soft tissues. Prototype hardware with appropriate software was produced and the method was successfully tested on magnetic microparticles injected into an excised pig liver. |
| Keywords: | New method Synchronous ultrasonic Doppler imaging Magnetic microsphere Microparticles and nanoparticles Soft biological tissue Magnetic modulation Ultrasound Doppler imaging |
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