Characterization of magnetic labels for bioassays |
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Authors: | Yoann Lalatonne,Farah Benyettou,Nicole Liè vre,Marc Lecouvey,Laurence Motte |
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Affiliation: | a Laboratoire CSPBAT FRE 3043 CNRS, Université Paris 13, Bobigny, France b Hôpital Avicenne, Service de Médecine Nucléaire, Bobigny, France c ESPCI ParisTech, Laboratoire de Physique Quantique 10 Rue Vauquelin, 75005 Paris, France d UPRES 3410 Biothérapies Bénéfices et Risques, France e ESPCI ParisTech, Laboratoire de Physique du Solide 10 Rue Vauquelin, 75005 Paris, France |
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Abstract: | Magnetic nanoparticles differing by their size have been synthesized to use them for multiparametric testing, based on their differing magnetic properties. The nanoparticle has two essential roles: to act as a probe owing to its specific magnetic properties and to carry on its surface precursor groups for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids. A totally unique, newly patented, method has been used to characterize magnetic signatures using the MIAplex technology. The MIAplex reader, developed by Magnisense, measures the non-linear response of the magnetic labels when they are exposed to a multi-frequency alternating magnetic field. This specific signature based on d2B(H)/dH2 was correlated to other more conventional magnetic detection methods (superconducting quantum interference devices (SQUID) and Mössbauer). |
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Keywords: | Nanoparticle Biosensor Biomedical application Magnetic property Non-linear superparamagnetic behaviour |
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