4-Aminobicyclo[2.2.2]octan-2-ones and -ols <Emphasis Type="Italic">via</Emphasis> Enamine Intermediates期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

4-Aminobicyclo[2.2.2]octan-2-ones and -ols via Enamine Intermediates

Authors:	Werner?Seebacher author-information" > author-information__contact u-icon-before" > mailto:we.seebacher@uni-graz.at" title=" we.seebacher@uni-graz.at" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Marcel?Kaiser,Reto?Brun,Robert?Saf,Robert?Weis

Affiliation:	(1) Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University of Graz, A-8010 Graz, Austria;(2) Swiss Tropical Institute, CH-4002 Basel, Switzerland;(3) Institute of Chemical Technology of Organic Materials, Erzherzog-Johann University, A-8010 Graz, Austria

Abstract:	Summary. The synthesis of new bicyclo[2.2.2]octane derivatives is described and their structures were established by NMR experiments. All compounds were tested in in vitro assays for their activities against causative organisms of malaria and African sleeping sickness and compared to those of former synthesized compounds.

Keywords:	. Antiplasmodial activity Antitrypanosomal activity Amino alcohols Cyclizations Structure-activity relationship.
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