Folipidine,a New Type Quinoline Alkaloid from Plants of the <Emphasis Type="Italic">Haplophyllum</Emphasis> Genus |
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| Authors: | V I Akhmedzhanova Kh A Rasulova I A Bessonova A S Shashkov N D Abdullaev L Angenot |
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| Institution: | (1) S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan;(2) N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow, B-334, Leninskii prospekt, 47, Russia;(3) Liege University, Belgium, B-4000 Liege, CHU, B36 |
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| Abstract: | The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT, 2D 1H-1H COSY, NOESY, and 1H-13C HSQC, HMBC, was isolated from two plants of the Haplophyllum genus. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of 3,4-b] conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity.__________Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 49–52, January–February, 2005. |
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| Keywords: | Haplophyllum foliosum H pedicellatum Rutaceae new quinoline alkaloid folipidine chemical transformations spectral data (UV IR mass NMR 2D 1H-1H COSY NOESY 1H-13C HSQC HMBC) antitumor activity |
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