Synthesis of Murisolin, (15R, 16R, 19R, 20S)‐Murisolin A,and (15R, 16R, 19S, 20S)‐16,19‐cis‐Murisolin and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I |
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| Authors: | Yasunao Hattori&#x; Yuka Kimura Aki Moroda Hiroyuki Konno Masato Abe Hideto Miyoshi Tetsuhisa Goto&#x; Hidefumi Makabe |
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| Institution: | Yasunao Hattori?,Yuka Kimura,Aki Moroda,Hiroyuki Konno,Masato Abe,Hideto Miyoshi,Tetsuhisa Goto?,Hidefumi Makabe |
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| Abstract: | The asymmetric total synthesis of murisolin, (15R, 16R, 19R, 20S)‐murisolin A, and (15R, 16R, 19S, 20S)‐16,19‐cis‐murisolin was performed by using an epoxy alcohol as a versatile chiral building block for synthesizing the stereoisomers of mono‐THF annonaceous acetogenins. The inhibitory activity of these murisolin compounds was examined with bovine heart mitochondrial complex I, and they showed almost the same activity. |
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| Keywords: | annonaceous acetogenins antitumor agents mitochondrial complex I natural products total synthesis |
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