| 盐酸多西环素的合成新方法 |
| |
| 引用本文： | 徐桂清,朱荣荣,毛雪莹,毛龙飞,吴斗灿,高原,姜玉钦,李伟.盐酸多西环素的合成新方法[J].合成化学,2019,27(2):145-148. |
| |
| 作者姓名： | 徐桂清 朱荣荣 毛雪莹 毛龙飞 吴斗灿 高原 姜玉钦 李伟 |
| |
| 作者单位： | 河南师范大学 化学化工学院 河南省手性醇类药物工程技术研究中心精细化学品绿色制造河南省协同创新中心 绿色化学介质与反应教育部重点实验室,河南 新乡,453007;上海大学 钱伟长学院,上海,200444;河南紫微星化学有限公司,河南 新乡,4453011 |
| |
| 基金项目： | 河南省科技创新杰出青年基金资助项目(164100510015) |
| |
| 摘 要： | 盐酸多西环素为重要的人兽两用药,其生产过程中的脱氯和不对称氢化反应对产品的收率和质量有重要影响。以11α-氯代甲烯土霉素为起始原料,自制钯炭为催化剂,经脱氯、氢化和转盐3步反应合成了盐酸多西环素,总收率达58.4%,其结构经~1H NMR确证。
|
| 关 键 词： | 盐酸多西环素 脱氯反应 不对称氢化反应 药物合成 |
| 收稿时间： | 2018-02-09 |
Novel Method for The Synthesis of Doxycycline Hydrochloride |
| |
| XU Gui-qing,ZHU Rong-rong,MAO Xue-ying,MAO Long-fei,WU Dou-can,GAO Yuan,JIANG Yu-qin,LI Wei.Novel Method for The Synthesis of Doxycycline Hydrochloride[J].Chinese Journal of Synthetic Chemistry,2019,27(2):145-148. |
| |
| Authors: | XU Gui-qing ZHU Rong-rong MAO Xue-ying MAO Long-fei WU Dou-can GAO Yuan JIANG Yu-qin LI Wei |
| |
| Institution: | 1. Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China;2. Qian Weichang College, Shanghai University, Shanghai 200444, China; 3. Hennan Ziweixing Chemistry Co., Ltd., Xinxiang 4453011, China |
| |
| Abstract: | XU Gui-qing;ZHU Rong-rong;MAO Xue-ying;MAO Long-fei;WU Dou-can;GAO Yuan;JIANG Yu-qin;LI Wei(Key Laboratory of Green Chemical Media and Reactions,Ministry of Education,Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals,Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China;Qian Weichang College,Shanghai University,Shanghai 200444,China;Hennan Ziweixing Chemistry Co.,Ltd.,Xinxiang 4453011,China) |
| |
| Keywords: | ,doxycycline hydrochloride,dechlorination,asymmetric hydrogenation,drug synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《合成化学》浏览原始摘要信息 |
| 点击此处可从《合成化学》下载免费的PDF全文 |
|
