温敏性抗菌水凝胶的制备与控释技术研究进展

温敏水凝胶是一类通过感知温度变化使自身发生相变的智能型聚合物凝胶,通过负载抗菌剂或抗菌性单体制备抗菌水凝胶是近年来药物控制释放、组织工程以及生物免疫等领域关注的热点。本文概述了负载抗菌剂型温敏性抗菌水凝胶的物理交联和化学交联制备技术的研究概况,着重阐述了温敏性抗菌水凝胶的孔径调控、制备材料调控、载药模式调控等技术的研究进展,并对温敏性抗菌水凝胶的控释技术应用前景,特别是在生物质材料领域的应用前景进行了展望。

Progress in Preparation and Controlled Release Technology of Thermo-Sensitive Antibacterial Hydrogels

Thermo-sensitive hydrogels are a class of intelligent polymer gels that undergo a phase change by sensing temperature changes. Preparation of antibacterial hydrogels by loading antibacterial agents or by antibacterial monomers is a hot spot in the fields of drug controlled release, tissue engineering and biological immunity in recent years. In this paper, the research progress in physical crosslinking and chemical crosslinking preparation technology of temperature-sensitive antibacterial hydrogels are reviewed. The control technology, such as the pore diameter, the preparation material and drug loading mode regulation is described. And the application of thermo-sensitive antibacterial hydrogel in controlled release technology, and especially the application prospect in the field of biomass materials are prospected.