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| 盐酸左西替利嗪片的近红外漫反射光谱定量分析 | |
| 引用本文： | 王琴,刘业海,高闽光,赵敏杰.盐酸左西替利嗪片的近红外漫反射光谱定量分析[J].光谱学与光谱分析,2016,36(12):3941-3944. |
| 作者姓名： | 王琴 刘业海 高闽光 赵敏杰 |
| 作者单位： | 1. 安徽医科大学第一附属医院耳鼻喉科，安徽 合肥 230022 2. 安徽医科大学附属合肥医院合肥市第二人民医院，安徽 合肥 230022 3. 安徽省环境光学监测技术重点实验室，中国科学院安徽光学精密机械研究所，安徽 合肥 230031 |
| 基金项目： | 中国科学院战略性先导科技专项(XDB05040200)，合肥市借转补项目(合科(2016)89号) |
| 摘 要： | 利用近红外光谱结合偏最小二乘法实现对不同品牌盐酸左西替利嗪片剂有效成分的定量分析。经内部交叉验证，确定最佳波数范围和光谱预处理方法，以及最佳主成分数，建立最优PLS校正模型。对验证集样品浓度进行预测，得到均方根误差RMSECV、决定系数R2分别为0.276和0.974。该方法能够用于不同厂家盐酸左西替利嗪片的快速定量分析，是一种有效的药品快速检验技术。 |
| 关 键 词： | 傅里叶光学 近红外光谱 盐酸左西替利嗪片 定量分析 |
| 收稿时间： | 2015-07-27 |
Quantitative Analysis for Levocetirizine Hydrochloride Tablets Based on NIR Spectroscopy |
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| WANG Qin,LIU Ye-hai,GAO Min-guang,ZHAO Min-jie.Quantitative Analysis for Levocetirizine Hydrochloride Tablets Based on NIR Spectroscopy[J].Spectroscopy and Spectral Analysis,2016,36(12):3941-3944. | |
| Authors: | WANG Qin LIU Ye-hai GAO Min-guang ZHAO Min-jie |
| Institution: | 1. Department of Otalaryngology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China2. Department of Otalaryngology, Hefei Second People’s Hospital of Anhui Medical University, Hefei 230022, China3. Key Laboratory of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China |
| Abstract: | The aim of this study was to develop a quantitative analytical method to measure the effective components in the left cetirizine hydrochloride tablets using near infrared spectroscopy combining with a partial least square (PLS)analysis model.The method was internal cross-validated to determine the best wavelength range,spectral preprocessing methods and the optimal number of principal components.The concentration of validation set samples was predictable by PLS model.The RMSECV val-ue was 0.276,and the R2 value was 0.974.Our study suggests that this model can be used for rapid quantitative analysis of left cetirizine hydrochloride tablets from different manufacturers. |
| Keywords: | Fourier optics Near infrared spectroscopy Levocetirizine hydrochloride tablet Quantitative analysis |
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