Synthesis,DNA-binding properties and cytotoxicity evaluation of two copper(II) complexes based on curcumin |
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| Authors: | Xuan?Xue Jiafeng?Wang Guifu?Si Chengming?Wang Email author" target="_blank">Shuangsheng?ZhouEmail author |
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| Institution: | 1.Department of Pharmacy,Anhui University of Chinese Medicine,Hefei,China;2.Anhui Province Key Laboratory of Environment-friendly Polymer Materials,Anhui University,Hefei,China;3.National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei,China |
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| Abstract: | Two Cu(II) complexes based on curcumin, namely CuL 2 1 HL1 = 1,7-bis4-(2-oxymethylenepyridine)-3-methoxyl]phenyl-1,6-heptadiene-3,5-diketone] and CuL 2 2 HL2 = 1,7-bis4-(3-oxymethylene-2-chlorothiophene)-3-methoxyl] phenyl-1,6-heptadiene-3,5-diketone], have been synthesized and characterized by physico-chemical and spectroscopic methods. The interactions of calf thymus DNA (CT-DNA) with both complexes have been investigated by UV–Vis absorption, fluorescence and viscosity titration methods. Both complexes are found to interact with CT-DNA by intercalative binding modes. Evaluation of the cytotoxicities of the complexes against three human tumor cells showed that they have potent cytotoxicities against all three cell lines. |
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